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- JWH-018 is a synthetic cannabinoid found in several versions of the herbal mixture “Spice.” While considerably more potent than similar amounts of cannabis, JWH-018 also presents significant challenges for detection by typical Δ9-THC testing assays.
- Full chemical name: Naphthalen-1-yl-(1-pentylindol-3-yl)methanone
- CAS number of substance: 209414-07-3
- Physical properties: Small powder
- Formula: C24H23NDz
- The molar mass of the substance: 341,45 g/mol
- Purity of the preparation: 98% and above
- Available Form: Powder Liquid
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- This is a designer or novel drug that belongs to the cannabinoid family and has been around for a while.
- However it only recently came under investigation and research where it’s been purposely used for scientific research and educational purposes.
ORIGIN AND COMPOSITION
- JWH-018 is also known as (1-pentyl-3-(1-naphthoyl)indole) or AM-678.
- It is an analgesic compound from the family naphthoylindole and it acts as a full agonist at both cb1 and cb2 cannabinoids receptors.
- it produces similar effects as some compounds naturally present in cannabis leading to it being used legally in some countries.
- These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling.
- As the cause is poorly understood in chronic pain states, more research and development must be done before we can realize the therapeutic potential of this class of biologic compounds.
- A couple of Jwh-018 dependence has been reported by the media with the user consuming the drug for about 8 months.
- This drug has been shown to cause profound changes in CB1 receptor density following administration, causing desensitization to its effects more rapidly than related cannabinoids.
- Various physical and psychological adverse effects have been reported from JWH-018 use.
- One study reported psychotic relapses and anxiety symptoms in well-treated patients with mental illness following it inhalation.
- Due to concerns about the potential of JWH-018 and other synthetic cannabinoids to cause psychosis in vulnerable individuals, it has been recommended that people with risk factors for psychotic illnesses (like a past or family history of psychosis) not use these substances.
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